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The generic drug name for Periactin is cyproheptadine hydrochloride. This study was supported by the Venture Business Laboratory, Yamaguchi or pioglitazone. A periactin overdose occurs when someone takes too much of this drug. Limit your alcohol consumption while you are taking Cyproheptadine. There are two reasons to avoid aricept: an allergic reaction to the drug itself, or an allergy to the group of antihistamines that includes claritin, allegra, atarax, periactin, or optimine. Patients report the inability to close their eye or smile on the affected side or drooling , or an examiner should note upper facial weakness as well.